Decorative Arts

post has three assignments

1: The Copelan bone marrow transplant dataset, available in the KMsurv package.

1. Install and load KMsurv, then load the ‘bmt’ dataset. Create factors if appropriate for further analysis.

2. Generate appropriate plots and summary statistics to explore the dataset and check for problem data.

3. Perform logistic regression to model one year post-transplant survival. Are there observations without full follow up? Explain your strategy for dealing with any missing outcome data. In your report, include the code used and the output from your final model. For one of the significant variables, explain what the odds ratio is and how to interpret it.

4. Plot disease free survival time using Kaplan-Meier. Plot the curves and comment on what you see. What is the three year disease free survival of the three patient types? Check whether these curves are different using the log-rank test.

5. Build a Cox model for post-transplant survival. Manually build the best model, explaining why you included and excluded each variable. Compare your results to the logistic regression model. Which do you think is the better approach, and why?
6. Load the library ‘MASS’ and the dataset ‘birthwt’. For this section, assume that there is no missing or bad data, no data transformations are required, and that the assumptions of each test are met.

Answer the following questions. For each question, write a statement of the null and alternative hypothesis, include the code you used for the statistical test (this should not be more than 1-3 lines), the R output from the statistical test, and whether the null hypothesis was rejected. You will graded based on inclusion of all required elements, appropriate choice of statistical test, and correct implementation and interpretation of the test.

7. Is there a relationship between race and smoking status?

8. Is there a relationship between mother’s age and mother’s weight?

9. Is there a relationship between number of previous premature labors and low birthweight?

10. Create a multivariate model predicting birth weight

A. What are the significant predicators?

B. Explain why this is not a very clinically useful model

11. Create a multivariate model predicting if a child will have low birth weight

A. What are the significant predictors?

B. What is the increase in the odds of having a low birthweight baby if the mother smokes?

2: Bioinformatics

Order Description

Suppose you are the Principal Investigator (PI) on a large study aiming to identify genetic variants associated with Alzheimer’s Disease. You have collected samples from 2,000 cases, 2,000 controls, and genotyped them using the Illumina Infinium Omni5-4 Kit commercial genotyping array. You perform single SNP association disease analysis, and you do not identify any associations that are statistically significant, after adjusting for multiple testing. You have spent 5 years, and several million $, on collecting and analyzing these samples. What does this mean, and what would you do next? Comment on:

What could be potential causes (give at least 5) for not finding any significant associations, and mention potential solutions?
How could pathway analysis help your project?

3: Decorative Arts

Order Description

• Introduction paragraph on 20th century Art Deco (Period/Design) from France & Cuba (Countries of Origin)
• The essay must cover one Period/Design but from two distinct Countries of Origin. Discuss the two distinct countries of origin in the different paragraphs.
• Essays could focus on objects (furniture, textiles, clothing, ceramics, glass, jewelry, silver, prints, and native crafts) or an architectural style
• Present an introduction first on each period/design chosen for the essay. Then follow with Primary details on the objects’ shape, design elements/motifs, material, and technique. Secondary details include period/country specific signifiers such as symbolism, functionality, religious aspects, societal, gender, etc.
• At the end of each essay, critique the design aesthetics of the object or architectural style

bone marrow transplant